The Protective Role of 4-Acetylarylquinolinol B in Different Pathological Processes

Abstract

Antrodia cinnamomea is a traditional plant and a unique fungus native to Taiwan that has been reported to have many biological functions, including anti-inflammatory and anticancer activities. The compound 4-acetylarylquinolinol B (4-AAQB) is one of the main bioactive compounds in the stamens of Antrodia cinnamomea, and has many biological functions, such as anti-inflammatory, antiproliferative, blood sugar reduction, antimetastasis, and vascular tone relaxation. In recent years, the increasing evidences have shown that 4-AAQB is involved in many diseases; however, the relevant mechanisms have not been fully clarified. This review aimed to clarify the improvement by 4-AAQB in different pathological processes, as well as the compound's molecular mechanisms, in order to provide a theoretical reference for future related research.

Figures

Figure 1

The chemical structure of 4-acetylarylquinolinol…

Figure 1

The chemical structure of 4-acetylarylquinolinol B.

Figure 1 The chemical structure of 4-acetylarylquinolinol B.

Figure 2

The proposed biosynthetic pathway of…

Figure 2

The proposed biosynthetic pathway of 4-acetylarylquinolinol B.

Figure 2 The proposed biosynthetic pathway of 4-acetylarylquinolinol B.

Figure 3

Schematic diagram of the antitumor…

Figure 3

Schematic diagram of the antitumor mechanism of 4-AAQB.

Figure 3 Schematic diagram of the antitumor mechanism of 4-AAQB.